منابع مشابه
Design and optimization of novel in situ gel of mercaptopurine for sustained drug delivery
Mercaptopurine is a purine antagonist, belonging to the class of antimetabolites. Its oral absorption is erratic and variable throughout GIT, with bioavailability of 5-37% and belongs to Biopharmaceutical Classification System (BCS) class IV. The focus of the present study was to improve solubility of mercaptopurine and to release the drug uniformly throughout the GIT by formulating into a nove...
متن کاملPreparation and characterization of 6-mercaptopurine-coated magnetite nanoparticles as a drug delivery system
BACKGROUND Iron oxide nanoparticles are of considerable interest because of their use in magnetic recording tape, ferrofluid, magnetic resonance imaging, drug delivery, and treatment of cancer. The specific morphology of nanoparticles confers an ability to load, carry, and release different types of drugs. METHODS AND RESULTS We synthesized superparamagnetic nanoparticles containing pure iron...
متن کاملLeucopenia resulting from a drug interaction between azathioprine or 6-mercaptopurine and mesalamine, sulphasalazine, or balsalazide.
AIM We evaluated the effect of coadministration of sulphasalazine, mesalamine, and balsalazide on the pharmacokinetics and pharmacodynamics of azathioprine and 6-mercaptopurine. METHODS Thirty four patients with Crohn's disease receiving azathioprine or 6-mercaptopurine were enrolled in an eight week non-randomised parallel group drug interaction study and treated with mesalamine 4 g/day, sul...
متن کاملProtective Effect on the Liver of Albino Rats Treated with 6 - Mercaptopurine Drug
The leukemia is considered to be one of the most frequent tumors in childhood. The first line of its treatment is 6-mercaptopurine (6-MP). There are many recorded cytotoxic effects for 6-mercaptopurine on tissues such as liver, pancreas and bone marrow. Nowadays the needs for administration of cytotoxic drugs are increased as the incidence of malignancies increases. So we have to search for a s...
متن کاملTherapeutic drug monitoring of azathioprine and 6-mercaptopurine metabolites in Crohn disease.
BACKGROUND 6-Mercaptopurine (6-MP) and its prodrug azathioprine (AZA) have proven efficacy in the treatment of Crohn disease (CD). The immunosuppressive properties of AZA/6-MP are mediated by the intracellular metabolism of 6-MP into its active metabolites, 6-thioguanine nucleotides (6TGN) and 6methylmercaptopurine (6-MMP). Preliminary studies have suggested that the red blood cell concentratio...
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ژورنال
عنوان ژورنال: Journal of Prescribing Practice
سال: 2020
ISSN: 2631-8385,2631-8393
DOI: 10.12968/jprp.2020.2.1.6